Certified Registered Nurse Infusion (CRNI) Practice Exam

When considering the administration of Rocephin (ceftriaxone), it is important to recognize the potential interactions that can arise with certain substances. The correct answer highlights the specific risks associated with using alcohol and aminoglycosides while on Rocephin. Rocephin can cause disulfiram-like reactions if taken with alcohol, which can lead to symptoms such as flushing, nausea, vomiting, and palpitations. This interaction arises because both alcohol and ceftriaxone can impair the metabolism of acetaldehyde, leading to increased levels in the body. It is crucial for patients to be aware of this potential reaction to avoid significant discomfort and health risks. Additionally, ceftriaxone can interact with aminoglycosides, a class of antibiotics. When used together, these medications can lead to increased risk of nephrotoxicity, as both drugs can compromise kidney function. The risks associated with concurrent use often necessitate careful monitoring of kidney function and potentially avoiding this combination whenever possible. While other substances, such as anticoagulants and beta-blockers, may have their own interactions with various medications, the specific consequences of combining Rocephin with alcohol and aminoglycosides highlight why this combination should be avoided. Understanding these