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Itching and rash are classic symptoms that can indicate an allergic reaction to an infusion. Allergic reactions occur when the immune system mistakenly identifies a substance, such as a medication or another component of the infusion, as harmful. This triggers the release of histamines and other chemicals in the body, leading to the development of symptoms such as itching and the appearance of rashes. These symptoms are often localized but can also be widespread, depending on the severity of the allergic response.

In contrast, symptoms such as fever and chills could suggest an infectious response rather than an allergic reaction. Lethargy and confusion may indicate systemic issues, such as metabolic disturbances or infection. Abdominal cramps might suggest gastrointestinal reactions or side effects rather than an allergic response specifically related to the infusion. Understanding these distinctions helps healthcare providers appropriately assess and respond to patient reactions during infusion therapy.