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Silicone is primarily used in PICC (Peripherally Inserted Central Catheter) lines due to its excellent biocompatibility and flexibility, but its main advantage lies in its ability to minimize the risk of thrombosis. The design and material of silicone tend to promote better blood flow characteristics within the catheter, which helps to reduce the likelihood of clot formation. The surface of silicone is smooth and less reactive with blood components compared to other materials, which contributes to this lower risk.

While flexibility is an important property of silicone, which allows for easier insertion and comfort, it is not the primary reason it is chosen for use in PICC lines. Additionally, while cost and infection prevention are important considerations for any medical device, the first priority identified in research and clinical outcomes for PICC lines is reducing thrombosis risk, making it a significant advantage of using silicone in these applications.