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When a patient cannot use penicillin due to an allergy or other contraindications, the recommended alternative is Vibramycin, also known as doxycycline. This medication belongs to the tetracycline class of antibiotics and is effective against a broad range of bacterial infections, making it a suitable option when penicillin is not appropriate.

Vibramycin works by inhibiting bacterial protein synthesis, thus disrupting the growth of susceptible bacteria. It's specifically useful for treating infections caused by organisms that are resistant to penicillin, such as some strains of staphylococci, as well as other infections like those from atypical pathogens.

The other choices provided are not typically recommended as direct substitutes for penicillin. Daptomycin, for instance, is used primarily for complicated skin infections and certain Gram-positive infections, while Tygacil (tigecycline) is often reserved for more complex infections and is not a first-line therapy. Chloramphenicol, although effective, is limited in its use due to potential severe side effects and its broad-spectrum nature, making it less preferable in situations where penicillin cannot be used.

Thus, considering the efficacy, safety, and current guidelines surrounding antibiotic usage, Vibramycin is the most appropriate alternative when penicillin cannot