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Etoposide is a chemotherapy medication commonly used to treat various types of cancer, including testicular cancer, lung cancer, and others. A notable side effect associated with its administration is hypotension, particularly when it is given as a rapid intravenous infusion. This drop in blood pressure can occur due to the histamine release stimulated by the drug, leading to vasodilation and decreased vascular tone.

While other side effects like vomiting, skin rash, and diarrhea can occur with Etoposide treatment, hypotension is especially characterized as a significant concern during its administration. It is essential for healthcare providers to monitor blood pressure closely during the infusion to manage and address any potential hypotensive episodes, thereby ensuring patient safety. The understanding of these side effects helps in preparing the patient and managing their care during chemotherapy treatments effectively.