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Osmolarity refers to the concentration of solute particles in a solution. A hypertonic solution is defined as one that has a higher concentration of solute compared to another solution, typically in reference to bodily fluids like blood plasma.

The correct choice indicates that hypertonic solutions have an osmolarity greater than 375 mOsm/L. This level of osmolarity means that when a hypertonic solution is administered to a patient, it causes water to move out of cells and into the surrounding fluid in order to balance solute concentrations, leading to cellular dehydration. This is clinically relevant in scenarios such as treating hyponatremia, where it might be necessary to correct an electrolyte imbalance by administering a hypertonic saline solution, which is often around 3% saline or 500-1000 mOsm/L in osmolarity.

The other options suggest osmolarity levels that either indicate isotonic or hypotonic solutions, which would not cause the same osmotic effects on cells. Therefore, options that define osmolarity lower than or equal to 250 mOsm/L, or between 250 mOsm/L and 375 mOsm/L, do not accurately reflect the defining characteristic of hyper