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The aminopenicillin that is noted for its instability in D5W (5% dextrose in water) and NS (normal saline) solutions is Omnipen, which is a brand name for ampicillin. This instability is significant because it affects the efficacy of the medication when it is reconstituted or diluted in these solutions.

In intravenous and parenteral treatments, the stability of a drug is crucial for ensuring that patients receive the intended dose and effectiveness. Ampicillin, specifically in its Omnipen formulation, has been shown to degrade in these solutions over time, which could potentially lead to decreased therapeutic levels and ineffective treatment if not monitored properly.

The other aminopenicillins listed may have different stability profiles, but Omnipen's noted instability sets it apart in this context, making it essential for healthcare professionals to take extra care when administering and preparing doses with this specific drug. Understanding these characteristics helps in optimizing treatment regimens and ensuring patient safety.