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Severe pain during infusion is a hallmark sign of chemical phlebitis, which often occurs as a result of irritation of the vein due to the infusion of certain medications or solutions. In cases of chemical phlebitis, the pain can be acute and is typically associated with the administration of irritant drugs that lead to inflammation of the vascular endothelium. This pain can be so pronounced that it is a key indicator for healthcare providers to evaluate the situation and possibly discontinue the intravenous infusion.

In addition to pain, other signs and symptoms may develop, which can include localized warmth, redness, and swelling but the immediate and severe pain is often the most distinct and identifiable initial symptom indicating the need for further assessment. This type of phlebitis can occur even without the presence of more classic signs such as redness along the vein or swelling, making severe pain a crucial factor in recognizing and addressing this condition quickly.