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Ceftazidime is a third-generation cephalosporin that is specifically indicated for use against Pseudomonas aeruginosa, a common and opportunistic pathogen known for its resistance to many antibiotics. This particular cephalosporin is effective due to its ability to penetrate the outer membrane of Gram-negative bacteria, including Pseudomonas, and its unique structure that enhances its activity against this organism.

Ceftazidime is often chosen for serious infections caused by Pseudomonas, particularly in immunocompromised patients or those with healthcare-associated infections. Its effectiveness in treating infections such as pneumonia, urinary tract infections, and bacteremia linked to this resistant pathogen makes it a critical option in the antimicrobial arsenal.

The other third-generation cephalosporins listed do not have reliable activity against Pseudomonas. For instance, cefotaxime and ceftriaxone primarily target strains of Streptococcus pneumoniae and other Gram-positive organisms, while cefepime, although it is a fourth-generation cephalosporin recognized for its broader spectrum including Pseudomonas, is not part of the third generation being asked about in this context. Thus, cefotaxime, ceftriaxone, and cef